The binding information is on the pack
What binds is always the labelling of the pack delivered to you. For this product the directions state two capsules daily and the recommended daily serving should not be exceeded.
That limit is not a safety reserve. With supplements, higher amounts rarely add benefit and mainly raise the likelihood of intolerance.
Timing, meals and fluid
There are no reliable data on an optimal time of day for glucosamine or MSM. Consistency is what matters, because a fixed habit is easier to sustain over weeks than a shifting one.
If capsules sit heavily, take them with a meal. Enough fluid, at least a large glass of water, helps with swallowing and transit. Capsules should not be swallowed dry.
Missed servings and the observation period
A missed serving is not made up and the next is not doubled. For a food supplement one missing serving has no consequences.
If you want to judge whether a product does anything for you, fix a start date and avoid changing diet, training volume and supplement at the same time. Otherwise no observation can be attributed afterwards.
Swallowing large capsules
Capsules holding several hundred milligrams of raw material are fairly large. Tilting the head slightly forward rather than back, and using plenty of water, usually helps.
Whether a capsule may be opened depends on the product. Unless the manufacturer says otherwise, leave the dosage form unchanged. With persistent swallowing difficulty a powder is the sensible alternative.